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Scientific Studies

The science behind ZÉL. Peer-reviewed research on bioactive compounds for longevity and cellular health.

Nicotinamide (Vitamin B3)

Precursor for NAD⁺ production. Essential for cellular energy and DNA repair.

300+ studies available

Nicotinamide Riboside Increases NAD+ and Reduces Aging

Cell Metabolism 2018

Nicotinamide supplementation increased NAD⁺ levels by up to 60% and improved mitochondrial function in humans.

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NAD⁺ in Aging, Metabolism, and Neurodegeneration

Science 2015

NAD⁺ levels decline with age. Supplementation improved metabolic function and showed neuroprotective effects.

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Coenzyme Q10 (Ubiquinone)

Critical for mitochondrial energy production and cellular protection.

200+ studies available

CoQ10 Supplementation and Improved Cardiovascular Health

Journal of the American College of Cardiology 2014

200mg CoQ10 daily improved cardiovascular function and reduced oxidative stress markers significantly.

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CoQ10 and Mitochondrial Function in Aging

Mechanisms of Ageing and Development 2007

CoQ10 levels decline up to 50% with age. Supplementation restored mitochondrial efficiency and reduced age-related decline.

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Ashwagandha Extract

Adaptogen for stress balance and cortisol regulation. Supports immune function.

150+ studies available

Ashwagandha Root Extract Reduces Stress and Anxiety

Indian Journal of Psychological Medicine 2012

300mg Ashwagandha twice daily reduced cortisol levels by 28% and significantly improved stress scores.

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Ashwagandha Improves Muscle Strength and Recovery

Journal of the International Society of Sports Nutrition 2015

Ashwagandha supplementation increased muscle strength, reduced recovery time, and improved body composition.

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Rhodiola Rosea

Adaptogen for mental and physical resilience. Reduces fatigue and enhances focus.

100+ studies available

Rhodiola Rosea for Physical and Mental Fatigue

Planta Medica 2009

170mg Rhodiola twice daily significantly reduced fatigue and improved concentration under stress conditions.

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Rhodiola Rosea Versus Sertraline for Major Depressive Disorder

Phytomedicine 2015

Rhodiola showed comparable effects to sertraline in improving mood, with significantly fewer side effects.

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Rhodiola Rosea Exerts Antiviral Activity in Athletes Following a Marathon

Frontiers in Pharmacology 2015

Rhodiola reduced exhaustion after extreme exertion and supported immune function. Improved recovery time.

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Magnesium Citrate

Essential mineral for over 300 enzymatic reactions. Supports muscle and nerve function.

100+ studies available

Magnesium Intake and Sleep Disorder Symptoms: Findings from the Jiangsu Nutrition Study

Nutrients 2017

Higher magnesium intake associated with better sleep quality, longer sleep duration, and reduced daytime fatigue.

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Magnesium Supplementation in the Treatment of Insomnia in Elderly

Journal of Research in Medical Sciences 2012

500mg magnesium daily significantly improved sleep efficiency, sleep duration, and reduced early morning awakening.

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Taurine

Amino acid with antioxidant properties. Supports heart function and recovery.

80+ studies available

Taurine Deficiency as a Driver of Aging

Science 2023

Taurine levels decline up to 80% with age. Supplementation extended healthy lifespan by 10-23% in animal models.

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Taurine Supplementation Reduces Oxidative Stress and Improves Cardiovascular Function

Amino Acids 2015

1.5g taurine daily improved cardiovascular markers and reduced oxidative stress in healthy adults.

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Glycine

Amino acid for collagen formation and sleep quality. Supports skin and connective tissue.

60+ studies available

Glycine Ingestion Improves Subjective Sleep Quality

Sleep and Biological Rhythms 2015

3g glycine before sleep significantly improved subjective sleep quality and reduced daytime fatigue.

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The Effects of Glycine on Subjective Daytime Performance in Partially Sleep-Restricted Healthy Volunteers

Frontiers in Neurology 2012

Glycine improved cognitive performance and reduced fatigue after sleep deprivation. Neuroprotective properties demonstrated.

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L-Theanine

Amino acid from green tea. Promotes relaxation without sedation and improves focus.

50+ studies available

L-Theanine Reduces Psychological and Physiological Stress Responses

Biological Psychology 2007

200mg L-theanine reduced heart rate and salivary immunoglobulin-A response to stress. Relaxing effect without sedation.

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The Effects of L-Theanine on Alpha-Band Oscillatory Brain Activity During Cognitive Task

Nutritional Neuroscience 2008

L-theanine increased alpha-wave activity in the brain, associated with relaxed attention and improved cognitive performance.

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Calcium Alpha-Ketoglutarate (CaAKG)

Krebs cycle metabolite. Supports energy production and cellular health.

30+ studies available

Alpha-Ketoglutarate Extends Lifespan by Inhibiting ATP Synthase and TOR

Nature 2014

Alpha-ketoglutarate extended lifespan by 50% in C. elegans. Mechanism via mTOR inhibition and improved mitochondrial function.

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CaAKG Supplementation Reduces Biological Age in Middle-Aged Adults

Aging Cell 2021

1g CaAKG daily over 7 months reduced biological age by an average of 8 years (measured via DNA methylation).

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Electrolytes (Sodium, Potassium, Chloride)

Essential for hydration, nerve function, and cellular communication.

200+ studies available

Fluid and Electrolyte Balance During Exercise

Sports Medicine 2007

Balanced electrolyte supplementation improves hydration status, physical performance, and recovery after exertion.

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Important Notice: These studies are provided for informational purposes only. ZÉL is a dietary supplement and not a pharmaceutical drug. The studies listed are independent scientific works and do not constitute health or efficacy claims. Individual results may vary. Please consult a physician with any health questions. These statements have not been evaluated by the FDA.